Medical Knowledge Cockpit hypoparathyroidism

• Amphetamine addiction
  Homo sapiens (human) one gene

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• Cocaine addiction
  Homo sapiens (human) one gene

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• Bile secretion
  Homo sapiens (human) one gene

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GATA3

Somatic tumors

breast

Tumor types germline

Cancer Syndrom

Translocation partner

Name

GATA binding protein 3

Chromosome banding

10p15

Cancer molecular gen.

Rec

Mutation type

F, N, S

Other syndrome disease

HDR syndrome (hypoparathyroidism, sensorineural deafness, and renal disease)

PTH

• A conditional knockout resource for the genome-wide study of mouse gene function
• Mouse library set to be knockout
• A mouse for all reasons
• Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes
• Advanced oxidation protein products, parathyroid hormone and vascular calcification in uremia

GATA3

• Expression of FOXA1 and GATA-3 in breast cancer: the prognostic significance in hormone receptor-negative tumours
• GATA-3 links tumor differentiation and dissemination in a luminal breast cancer model
• Prognosis of hormone-dependent breast cancers: implications of the presence of dysfunctional transcriptional networks activated by insulin via the immune transcription factor T-bet
• TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3
• Transcriptional activity of TAL1 in T cell acute lymphoblastic leukemia (T-ALL) requires RBTN1 or -2 and induces TALLA1, a highly specific tumor marker of T-ALL

TBCE

• Pathway leading to correctly folded beta-tubulin

GNAS

• Genetics of McCune-Albright syndrome

STX16

• How Tlg2p/syntaxin 16 'snares' Vps45