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NTRK1
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NTRK1
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is amembrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway.The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuronsubtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis,self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this genehave been found, but only three have been characterized to date. (provided by RefSeq, Jul 2008)This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family
This kinase is amembrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway.The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuronsubtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis,self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this genehave been found, but only three have been characterized to date. (provided by RefSeq, Jul 2008)
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