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NTRK1

Somatic tumors
papillary thyroid, Spitzoid tumour
Tumor types germline
Cancer Syndrom
Translocation partner
TPM3, TPR, TFG, TP53, LMNA
Name
neurotrophic tyrosine kinase, receptor, type 1
Chromosome banding
1q21-q22
Cancer molecular gen.
Dom
Mutation type
T, A
Other syndrome disease
Definition     No results

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NTRK1

This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is amembrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway.The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuronsubtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis,self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this genehave been found, but only three have been characterized to date. (provided by RefSeq, Jul 2008)

This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family

This kinase is amembrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway.The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuronsubtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis,self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this genehave been found, but only three have been characterized to date. (provided by RefSeq, Jul 2008)

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