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insulin resistance
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basic mechanism of action of ppara pparb(d) and pparg and effects on gene expression
species not specified
one gene
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Cancer Gene Census
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PPARG
Somatic tumors
follicular thyroid
Tumor types germline
Cancer Syndrom
Translocation partner
PAX8
Name
peroxisome proliferative activated receptor, gamma
Chromosome banding
3p25
Cancer molecular gen.
Dom
Mutation type
T
Other syndrome disease
Insulin resistance ; lipodystrophy, familial partial L;diabetes mellitus, insulin-resistantI, with acanthosis nigricans and hypertension
Definition
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PPARG
Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism
A PPARgamma mutant serves as a dominant negative inhibitor of PPAR signaling and is localized in the nucleus
Asymmetry in the PPARgamma/RXRalpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors
PPP1R3A
Sequence of the human glycogen-associated regulatory subunit of type 1 protein phosphatase and analysis of its coding region and mRNA level in muscle from patients with NIDDM
RETN
Insulin resistance and type 2 diabetes are not related to resistin expression in human fat cells or skeletal muscle
Relationship between serum resistin concentrations and insulin resistance in nonobese, obese, and obese diabetic subjects
Resistin / Fizz3 expression in relation to obesity and peroxisome proliferator-activated receptor-gamma action in humans
Adipose tissue resistin expression is severely suppressed in obesity and stimulated by peroxisome proliferator-activated receptor gamma agonists
Human resistin gene: molecular scanning and evaluation of association with insulin sensitivity and type 2 diabetes in Caucasians
PTPN1
Protein tyrosine phosphatase 1B deficiency or inhibition delays ErbB2-induced mammary tumorigenesis and protects from lung metastasis
Protein-tyrosine phosphatase 1B is required for HER2/Neu-induced breast cancer
Genetic ablation of protein tyrosine phosphatase 1B accelerates lymphomagenesis of p53-null mice through the regulation of B-cell development
Protein tyrosine phosphatases in the human genome.
Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate