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leiomyoma
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HMGA2
HMGI/Y proteins: flexible regulators of transcription and chromatin structure.
cDNA cloning of the HMGI-C phosphoprotein, a nuclear protein associated with neoplastic and undifferentiated phenotypes
The gene for the human architectural transcription factor HMGI-C consists of five exons each coding for a distinct functional element
Identification, molecular cloning, and characterization of the chromosome 12 breakpoint cluster region of uterine leiomyomas
Disruption of the architectural factor HMGI-C: DNA-binding AT hook motifs fused in lipomas to distinct transcriptional regulatory domains
FH
Structure of free fumarase C from Escherichia coli
TSC1
Tsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagy
Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase
The TSC1 tumor suppressor hamartin interacts with neurofilament-L and possibly functions as a novel integrator of the neuronal cytoskeleton
TSC2
Activation of protein synthesis in cardiomyocytes by the hypertrophic agent phenylephrine requires the activation of ERK and involves phosphorylation of tuberous sclerosis complex 2 (TSC2)
Human papillomavirus 16 E6 oncoprotein interferences with insulin signaling pathway by binding to tuberin
E3 ubiquitin ligase E6AP-mediated TSC2 turnover in the presence and absence of HPV16 E6
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HMGA2
Somatic tumors
lipoma, leiomyoma, pleomorphic salivary gland adenoma
Tumor types germline
Cancer Syndrom
Translocation partner
LHFP, RAD51B, LPP, COX6C, ACKR3, NFIB, ALDH2, CCNB1IP1, EBF1, WIF1, FHIT
Name
high mobility group AT-hook 2 (HMGIC)
Chromosome banding
12q15
Cancer molecular gen.
Dom
Mutation type
T
Other syndrome disease
Pathways
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Ã
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mTOR signaling pathway
Homo sapiens (human)
2 genes
Definition
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