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RAF1

Cancer Gene Census     No results

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BRAF

Somatic tumors
melanoma, colorectal, papillary thyroid, borderline ovarian, NSCLC, cholangiocarcinoma, pilocytic astrocytoma, Spitzoid tumour, pancreas acinar carcinoma, melanocytic nevus, prostate, gastric
Tumor types germline
Cancer Syndrom
Translocation partner
AKAP9, KIAA1549, CEP88, LSM14A, SND1, FCHSD1, SLC45A3, FAM131B, RNF130, CLCN6, MKRN1, GNAI1, AGTRAP
Name
v-raf murine sarcoma viral oncogene homolog B1
Chromosome banding
7q34
Cancer molecular gen.
Dom
Mutation type
Mis, T, O
Other syndrome disease
Cardio-facio-cutaneous syndrome
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Pathways     No results

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  • Neurotrophin signaling pathway
    Homo sapiens (human) 3 genes
  • Renal cell carcinoma
    Homo sapiens (human) 3 genes
  • igf-1 signaling pathway
    species not specified 2 genes
  • Insulin signaling pathway
    Homo sapiens (human) 2 genes
  • Alcoholism
    Homo sapiens (human) 2 genes
  • Hepatitis C
    Homo sapiens (human) 2 genes
  • Pathways in cancer
    Homo sapiens (human) 2 genes
  • Colorectal cancer
    Homo sapiens (human) 2 genes
  • Pancreatic cancer
    Homo sapiens (human) 2 genes
  • Endometrial cancer
    Homo sapiens (human) 2 genes
  • Glioma
    Homo sapiens (human) 2 genes
  • Prostate cancer
    Homo sapiens (human) 2 genes
Definition     No results

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BRAF

This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This proteinplays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation,and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterizedby heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also beenassociated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroidcarcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located onchromosome X, has been identified for this gene. (provided by RefSeq, Jul 2008)

This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases

This proteinplays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation,and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterizedby heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also beenassociated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroidcarcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located onchromosome X, has been identified for this gene. (provided by RefSeq, Jul 2008)