Medical Knowledge Cockpit leukemia, acute lymphoblastic

LMO1

• The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13

NOTCH1

• Structural requirements for assembly of the CSL.intracellular Notch1.Mastermind-like 1 transcriptional activation complex
• Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription
• The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity

NUP214

• Cloning and characterization of human karyopherin beta3
• Karyopherin beta2 mediates nuclear import of a mRNA binding protein
• Nup84, a novel nucleoporin that is associated with CAN/Nup214 on the cytoplasmic face of the nuclear pore complex

TCF3

• Transcriptional synergy between LIM-homeodomain proteins and basic helix-loop-helix proteins: the LIM2 domain determines specificity
• Helix-loop-helix proteins LYL1 and E2a form heterodimeric complexes with distinctive DNA-binding properties in hematolymphoid cells

IKZF1

• Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes
• Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes
• Eos: a novel member of the Ikaros gene family expressed predominantly in the developing nervous system
• Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities

FLT3

• Compassionate use of sorafenib in FLT3-ITD-positive acute myeloid leukemia: sustained regression before and after allogeneic stem cell transplantation

TAL2

• Distinct t(7;9)(q34;q32) breakpoints in healthy individuals and individuals with T-ALL

PAX5

• Long-term in vivo reconstitution of T-cell development by Pax5-deficient B-cell progenitors
• BSAP (Pax5)-importin alpha 1 (Rch1) interaction identifies a nuclear localization sequence
• Transcriptional repression by Pax5 (BSAP) through interaction with corepressors of the Groucho family

HOXD4

• Complete mutation analysis panel of the 39 human HOX genes
• Mutation analysis of the HOX paralogous 4-13 genes in children with acute lymphoid malignancies: identification of a novel germline mutation of HOXD4 leading to a partial loss-of-function

TAL2

Somatic tumors

T-ALL

Tumor types germline

Cancer Syndrom

Translocation partner

TRB

Name

T-cell acute lymphocytic leukemia 2

Chromosome banding

9q31

Cancer molecular gen.

Dom

Mutation type

T

Other syndrome disease

• Acute myeloid leukemia
  Homo sapiens (human) one gene

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