Medical Knowledge Cockpit leukemia, acute pre-b-cell

PBX1

• Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity
• Two-step regulation of Ad4BP/SF-1 gene transcription during fetal adrenal development: initiation by a Hox-Pbx1-Prep1 complex and maintenance via autoregulation by Ad4BP/SF-1
• B-cell development fails in the absence of the Pbx1 proto-oncogene
• Pancreas duodenum homeobox-1 regulates pancreas development during embryogenesis and islet cell function in adulthood

PBX1

Somatic tumors

pre B-ALL, myoepithelioma

Tumor types germline

Cancer Syndrom

Translocation partner

TCF3, EWSR1

Name

pre-B-cell leukemia transcription factor 1

Chromosome banding

1q23

Cancer molecular gen.

Dom

Mutation type

T

Other syndrome disease