Medical Knowledge Cockpit
leukemia, acute promyelocytic, pml/rara type
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PML
Promyelocytic leukemia is a direct inhibitor of SAPK2/p38 mitogen-activated protein kinase
c-Myb associates with PML in nuclear bodies in hematopoietic cells
MDM2 and promyelocytic leukemia antagonize each other through their direct interaction with p53
Physical and functional interactions between PML and MDM2
Promyelocytic leukemia protein PML inhibits Nur77-mediated transcription through specific functional interactions
Arsenic trioxide is a potent inhibitor of the interaction of SMRT corepressor with Its transcription factor partners, including the PML-retinoic acid receptor alpha oncoprotein found in human acute promyelocytic leukemia
Cancer Gene Census
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PML
Somatic tumors
APL, ALL
Tumor types germline
Cancer Syndrom
Translocation partner
RARA, PAX5
Name
promyelocytic leukemia
Chromosome banding
15q22
Cancer molecular gen.
Dom
Mutation type
T
Other syndrome disease
Definition
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Pathways
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Clinical Trials
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External
Simplified Patient Care Strategy in Decreasing Early Death in Patients With Acute Promyelocytic Leukemia
AIDA 2000 Guidelines
Connect® MDS/AML Disease Registry
Study to Improve OS in 18 to 60 Year-old Patients, Comparing Daunorubicin Versus High Dose Idarubicin Induction Regimens, High Dose Versus Intermediate Dose Cytarabine Consolidation Regimens, and Standard Versus MMF Prophylaxis of GvHD in Allografted Patients in First CR (BIG-1)