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leukemia, acute promyelocytic
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RARA
Acute promyelocytic leukemia: new issues on pathogenesis and treatment response
Interaction of BAG-1 with retinoic acid receptor and its inhibition of retinoic acid-induced apoptosis in cancer cells
Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: a humoral mechanism to reset a peripheral clock
Cyclin D3 is a cofactor of retinoic acid receptors, modulating their activity in the presence of cellular retinoic acid-binding protein II
Two distinct nuclear receptor-interaction domains and CREB-binding protein-dependent transactivation function of activating signal cointegrator-2
A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo
NPM1
Nuclear Akt interacts with B23/NPM and protects it from proteolytic cleavage, enhancing cell survival
NUMA1
Assignment of the nuclear mitotic apparatus protein NuMA gene to human chromosome 11q13
ZBTB16
A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF
The ETO Protein Disrupted in t(8;21)-Associated Acute Myeloid Leukemia Is a Corepressor for the Promyelocytic Leukemia Zinc Finger Protein
Epsin 1 Undergoes Nucleocytosolic Shuttling and Its Eps15 Interactor Nh2-Terminal Homology (Enth) Domain, Structurally Similar to Armadillo and Heat Repeats, Interacts with the Transcription Factor Promyelocytic Leukemia Zn2+ Finger Protein (Plzf)
AML-1/ETO fusion protein is a dominant negative inhibitor of transcriptional repression by the promyelocytic leukemia zinc finger protein
Targeting the Acute Promyelocytic Leukemia-Associated Fusion Proteins PML/RAR���� and PLZF/RAR���� with Interfering Peptides
Two critical hits for promyelocytic leukemia
PML
Interactive Organization of the Circadian Core Regulators PER2, BMAL1, CLOCK and PML
The transcriptional role of PML and the nuclear body
PML protein isoforms and the RBCC/TRIM motif
PML interaction with p53 and its role in apoptosis and replicative senescence
The role of PML in tumor suppression
An assessment of progress in the use of alternatives in toxicity testing since the publication of the report of the second FRAME Toxicity Committee (1991)
STAT5B
Cytosolic tyrosine dephosphorylation of STAT5. Potential role of SHP-2 in STAT5 regulation
Cancer Gene Census
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PML
Somatic tumors
APL, ALL
Tumor types germline
Cancer Syndrom
Translocation partner
RARA, PAX5
Name
promyelocytic leukemia
Chromosome banding
15q22
Cancer molecular gen.
Dom
Mutation type
T
Other syndrome disease
Definition
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Pathways
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Modal title
degradation of the rar and rxr by the proteasome
species not specified
one gene
Clinical Trials
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External
Pfizer Immunotherapy Combinations for Acute Myeloid Leukemia (AML) Multi-Arm Study 1
Gemtuzumab Ozogamicin With G-CSF, Cladribine, Cytarabine and Mitoxantrone in Treating Participants With Previously Untreated Acute Myeloid Leukemia or High-Grade Myeloid Neoplasm
Study of Haplo-HSCT + BPX-501 vs Haplo-HSCT + Post Transplant Cyclophosphamide in Patients With AML or MDS (THRIVE)