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ABL1

Somatic tumors
CML, ALL, T-ALL
Tumor types germline
Cancer Syndrom
Translocation partner
BCR, ETV6, NUP214
Name
v-abl Abelson murine leukemia viral oncogene homolog 1
Chromosome banding
9q34.1
Cancer molecular gen.
Dom
Mutation type
T, Mis
Other syndrome disease
Definition     No results

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ABL1

The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated inprocesses of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl proteinis negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. Thet(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in manycases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosinekinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene isexpressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the commonexons 2-11. (provided by RefSeq, Jul 2008)

The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated inprocesses of cell differentiation, cell division, cell adhesion, and stress response

Activity of c-Abl proteinis negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. Thet(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in manycases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosinekinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene isexpressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the commonexons 2-11. (provided by RefSeq, Jul 2008)

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