An error occurred
An error occurred
ABL1
An error occurred
ABL1
The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated inprocesses of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl proteinis negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. Thet(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in manycases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosinekinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene isexpressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the commonexons 2-11. (provided by RefSeq, Jul 2008)The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated inprocesses of cell differentiation, cell division, cell adhesion, and stress response
Activity of c-Abl proteinis negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. Thet(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in manycases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosinekinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene isexpressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the commonexons 2-11. (provided by RefSeq, Jul 2008)
An error occurred
An error occurred