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leukemia/lymphoma, b-cell
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BCL2
The p53-binding protein 53BP2 also interacts with Bc12 and impedes cell cycle progression at G2/M
Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation
Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation
Overexpression of nucleolin in chronic lymphocytic leukemia cells induces stabilization of bcl2 mRNA
Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells
Saving death: apoptosis for intervention in transplantation and autoimmunity
BCL3
Activation of nuclear factor-kappaB p50 homodimer/Bcl-3 complexes in nasopharyngeal carcinoma
The oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimers
The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators
Cancer Gene Census
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BCL3
Somatic tumors
CLL
Tumor types germline
Cancer Syndrom
Translocation partner
IGH
Name
B-cell CLL/lymphoma 3
Chromosome banding
19q13
Cancer molecular gen.
Dom
Mutation type
T
Other syndrome disease
Definition
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Pathways
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Pathways in cancer
Homo sapiens (human)
one gene
Hepatitis B
Homo sapiens (human)
one gene
Clinical Trials
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External
Study of Venetoclax, a BCL2 Antagonist, for Patients With Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)
IP3R Modulation by Cancer Genes in Mesothelioma