Medical Knowledge Cockpit leukemia/lymphoma, t-cell

• PI3K-Akt signaling pathway
  Homo sapiens (human) 2 genes

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TCL1A

• A modeled hydrophobic domain on the TCL1 oncoprotein mediates association with AKT at the cytoplasmic membrane
• Differential expression of TCL1 during pre-B-cell acute lymphoblastic leukemia progression

TCL1B

• Abnormalities at 14q32.1 in T cell malignancies involve two oncogenes

TCL1A

Somatic tumors

T-CLL

Tumor types germline

Cancer Syndrom

Translocation partner

TRA

Name

T-cell leukemia/lymphoma 1A

Chromosome banding

14q32.1

Cancer molecular gen.

Dom

Mutation type

T

Other syndrome disease