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leukemia/lymphoma
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hiv-1 nef: negative effector of fas and tnf
species not specified
one gene
regulation of bad phosphorylation
species not specified
one gene
Clinical Trials
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Anti-CD19 CAR-T Cells With Inducible Caspase 9 Safety Switch for B-cell Lymphoma
Cancer Gene Census
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TCL1A
Somatic tumors
T-CLL
Tumor types germline
Cancer Syndrom
Translocation partner
TRA
Name
T-cell leukemia/lymphoma 1A
Chromosome banding
14q32.1
Cancer molecular gen.
Dom
Mutation type
T
Other syndrome disease
PubMed Links
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BCL2
The p53-binding protein 53BP2 also interacts with Bc12 and impedes cell cycle progression at G2/M
Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation
Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation
Overexpression of nucleolin in chronic lymphocytic leukemia cells induces stabilization of bcl2 mRNA
Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells
Saving death: apoptosis for intervention in transplantation and autoimmunity
BCL3
Activation of nuclear factor-kappaB p50 homodimer/Bcl-3 complexes in nasopharyngeal carcinoma
The oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimers
The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators
TCL1A
Crystal structure of p14TCL1, an oncogene product involved in T-cell prolymphocytic leukemia, reveals a novel beta-barrel topology
Expression of the TCL1 gene at 14q32 in B-cell malignancies but not in adult T-cell leukemia
TCL1B
Abnormalities at 14q32.1 in T cell malignancies involve two oncogenes
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