Medical Knowledge Cockpit lipodystrophy, familial partial, type 3

PPARG

• Honokiol: a non-adipogenic PPAR�� agonist from nature
• Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism
• A PPARgamma mutant serves as a dominant negative inhibitor of PPAR signaling and is localized in the nucleus

 

PPARG

Somatic tumors

follicular thyroid

Tumor types germline

Cancer Syndrom

Translocation partner

PAX8

Name

peroxisome proliferative activated receptor, gamma

Chromosome banding

3p25

Cancer molecular gen.

Dom

Mutation type

T

Other syndrome disease

Insulin resistance ; lipodystrophy, familial partial L;diabetes mellitus, insulin-resistantI, with acanthosis nigricans and hypertension

 

PPARG

This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclearreceptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcriptionof various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encodedby this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has beenimplicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer.Alternatively spliced transcript variants that encode different isoforms have been described. (provided byRefSeq, Jul 2008)

This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclearreceptors

PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcriptionof various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encodedby this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has beenimplicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer.Alternatively spliced transcript variants that encode different isoforms have been described. (provided byRefSeq, Jul 2008)