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KRAS
MAP3K8
EGFR
BRAF
IRF1
PIK3CA
CASP8
CYP2A6
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PIK3CA
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DLEC1
This gene contains 37 exons, spans approximately 59-kb, and is located in the 3p22-p21.3 chromosomal segment thatis commonly deleted in various carcinomas. Several alternatively spliced transcripts have been observed thatcontain disrupted coding regions and likely encode nonfunctional proteins. Aberrant transcription of this genemay be involved in carcinogenesis of the lung, esophagus, and kidney. (provided by RefSeq, Jul 2008)This gene contains 37 exons, spans approximately 59-kb, and is located in the 3p22-p21
3 chromosomal segment thatis commonly deleted in various carcinomas. Several alternatively spliced transcripts have been observed thatcontain disrupted coding regions and likely encode nonfunctional proteins. Aberrant transcription of this genemay be involved in carcinogenesis of the lung, esophagus, and kidney. (provided by RefSeq, Jul 2008)
RASSF1
This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has beenassociated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of thisgene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-islandpromoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was alsoshown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively splicedtranscript variants of this gene encoding distinct isoforms have been reported. (provided by RefSeq, May 2011)This gene encodes a protein similar to the RAS effector proteins
Loss or altered expression of this gene has beenassociated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of thisgene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-islandpromoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was alsoshown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively splicedtranscript variants of this gene encoding distinct isoforms have been reported. (provided by RefSeq, May 2011)
PPP2R1B
This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the fourmajor Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consistsof a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit,that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffoldingmolecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This geneencodes a beta isoform of the constant regulatory subunit A. Mutations in this gene have been associated withsome lung and colon cancers. Alternatively spliced transcript variants have been described. (provided by RefSeq,Apr 2010)This gene encodes a constant regulatory subunit of protein phosphatase 2
Protein phosphatase 2 is one of the fourmajor Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consistsof a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit,that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffoldingmolecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This geneencodes a beta isoform of the constant regulatory subunit A. Mutations in this gene have been associated withsome lung and colon cancers. Alternatively spliced transcript variants have been described. (provided by RefSeq,Apr 2010)
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