Medical Knowledge Cockpit lymphedema, hereditary

FLT4

• Chromosomal localization of FLT4, a novel receptor-type tyrosine kinase gene

GJC2

• Rapid identification of mutations in GJC2 in primary lymphoedema using whole exome sequencing combined with linkage analysis with delineation of the phenotype.

 

FLT4

Somatic tumors

soft tissue sarcoma

Tumor types germline

Cancer Syndrom

Translocation partner

Name

fms-related tyrosine kinase 4

Chromosome banding

5q35.3

Cancer molecular gen.

Dom

Mutation type

A

Other syndrome disease

 

FLT4

This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein isthought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this genecause hereditary lymphedema type IA. (provided by RefSeq, Jul 2008)

This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D

The protein isthought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this genecause hereditary lymphedema type IA. (provided by RefSeq, Jul 2008)

 

• PI3K-Akt signaling pathway
  Homo sapiens (human) one gene

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