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lymphoma, non-hodgkin, somatic
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ATM
Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites. In vivo assessment using phospho-specific antibodies
Functional link between BLM defective in Bloom's syndrome and the ataxia-telangiectasia-mutated protein, ATM
Recruitment of ATM protein to double strand DNA irradiated with ionizing radiation
RAD54B
Mutations of a novel human RAD54 homologue, RAD54B, in primary cancer
RAD54L
Human and mouse homologs of the Saccharomyces cerevisiae RAD54 DNA repair gene: evidence for functional conservation
Cancer Gene Census
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ATM
Somatic tumors
T-PLL
Tumor types germline
leukaemia, lymphoma, medulloblastoma, glioma
Cancer Syndrom
ataxia-telangiectasia
Translocation partner
Name
ataxia telangiectasia mutated
Chromosome banding
11q22.3
Cancer molecular gen.
Rec
Mutation type
D, Mis, N, F, S
Other syndrome disease
Pathways
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rb tumor suppressor/checkpoint signaling in response to dna damage
species not specified
one gene
cdc25 and chk1 regulatory pathway in response to dna damage
species not specified
one gene
Clinical Trials
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External
A Study of Atezolizumab as Adjuvant Therapy in Participants With Renal Cell Carcinoma (RCC) at High Risk of Developing Metastasis Following Nephrectomy (IMmotion010)
Definition
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