Medical Knowledge Cockpit lymphoma, somatic

ATM

• Accumulation of checkpoint protein 53BP1 at DNA breaks involves its binding to phosphorylated histone H2AX
• Mitochondrial dysfunction in ataxia-telangiectasia
• The BRCA1/2 pathway prevents hematologic cancers in addition to breast and ovarian cancers

BCL10

• Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure
• Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B
• Bcl10 and MALT1, independent targets of chromosomal translocation in malt lymphoma, cooperate in a novel NF-kappa B signaling pathway
• CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B

RAD54B

• A novel human rad54 homologue, Rad54B, associates with Rad51

RAD54L

• Human and mouse homologs of the Saccharomyces cerevisiae RAD54 DNA repair gene: evidence for functional conservation

MAD1L1

• Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1

CASP10

• In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains

 

CASP10

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequentialactivation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactiveproenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large andsmall, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and theprotein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmunelymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variantsencoding different isoforms have been described for this gene. (provided by RefSeq, Apr 2011)

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family

Sequentialactivation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactiveproenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large andsmall, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and theprotein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmunelymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variantsencoding different isoforms have been described for this gene. (provided by RefSeq, Apr 2011)

 

BCL10

Somatic tumors

MALT

Tumor types germline

Cancer Syndrom

Translocation partner

IGH

Name

B-cell CLL/lymphoma 10

Chromosome banding

1p22

Cancer molecular gen.

Dom

Mutation type

T

Other syndrome disease

 

• p53 signaling pathway
  Homo sapiens (human) one gene

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• Cell cycle
  Homo sapiens (human) 2 genes

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• Apoptosis
  Homo sapiens (human) 2 genes

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