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lymphoproliferative syndrome
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Pathways
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Natural killer cell mediated cytotoxicity
Homo sapiens (human)
2 genes
T cell receptor signaling pathway
Homo sapiens (human)
2 genes
Chemokine signaling pathway
Homo sapiens (human)
2 genes
Hepatitis B
Homo sapiens (human)
2 genes
Apoptosis
Homo sapiens (human)
2 genes
caspase cascade in apoptosis
species not specified
2 genes
Clinical Trials
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External
Open Label Study Investigating the Safety and Efficacy of Blinatumomab in Combination With Pembrolizumab (KEYNOTE-348)
Cancer Gene Census
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ITK
Somatic tumors
peripheral T-cell lymphoma
Tumor types germline
Cancer Syndrom
Translocation partner
SYK
Name
IL2-inducible T-cell kinase
Chromosome banding
5q31-q32
Cancer molecular gen.
Dom
Mutation type
T
Other syndrome disease
PubMed Links
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NRAS
Isolation and preliminary characterization of the transforming gene of a human neuroblastoma cell line
CASP10
In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains
ITK
Evidence that the Wiskott-Aldrich syndrome protein may be involved in lymphoid cell signaling pathways
Identification, cloning, and characterization of a novel human T-cell-specific tyrosine kinase located at the hematopoietin complex on chromosome 5q
SH2D1A
The X-linked lymphoproliferative syndrome gene product SH2D1A associates with p62dok (Dok1) and activates NF-kappa B
Dual functional roles for the X-linked lymphoproliferative syndrome gene product SAP/SH2D1A in signaling through the signaling lymphocyte activation molecule (SLAM) family of immune receptors
SAP couples Fyn to SLAM immune receptors
Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients
XIAP
The polypeptide chain-releasing factor GSPT1/eRF3 is proteolytically processed into an IAP-binding protein
Neurotrophin receptor-interacting mage homologue is an inducible inhibitor of apoptosis protein-interacting protein that augments cell death
XIAP regulates bi-phasic NF-kappaB induction involving physical interaction and ubiquitination of MEKK2
XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway
Definition
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