Medical Knowledge Cockpit maturity-onset diabetes of the young

NEUROD1

• The islet beta cell-enriched MafA activator is a key regulator of insulin gene transcription
• Cyclin D1 represses the basic helix-loop-helix transcription factor, BETA2/NeuroD
• Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young

INS

• A reappraisal of the blood glucose homeostat which comprehensively explains the type 2 diabetes mellitus-syndrome X complex
• What's fueling the biotech engine-2011 to 2012
• Insulin-related material in microbes: similarities and differences from mammalian insulins
• A review of piscine islet xenotransplantation using wild-type tilapia donors and the production of transgenic tilapia expressing a "humanized" tilapia insulin
• Specialized insulin is used for chemical warfare by fish-hunting cone snails

• Sequence of the human insulin gene
• Regulation of insulin gene transcription
• Glucocorticoid receptor mediated repression of human insulin gene expression is regulated by PGC-1alpha

BLK

• Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination

PAX4

• Regulation of Pax4 paired homeodomain gene by neuron-restrictive silencer factor
• Interaction and association analysis of a type 1 diabetes susceptibility locus on chromosome 5q11-q13 and the 7q32 chromosomal region in Scandinavian families

KLF11

• The Kr����ppel-like factor 11 (KLF11) Q62R polymorphism is not associated with type 2 diabetes in 8,676 people
• Functional domains of the TGF-beta-inducible transcription factor Tieg3 and detection of two putative nuclear localization signals within the zinc finger DNA-binding domain

CEL

• Bile salt-dependent lipase: its pathophysiological implications

• Regulation of beta-cell development
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• Insulin Synthesis and Processing
  species not specified one gene

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