Medical Knowledge Cockpit megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome

AKT3

• Role of 14-3-3epsilon, c-Myc/Max, and Akt phosphorylation in HIV-1 gp 120-induced mesangial cell proliferation
• Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs
• Enhanced stimulation of Akt-3/protein kinase B-gamma in human aortic smooth muscle cells

PIK3R2

• Tyrosine phosphorylation of Cbl upon epidermal growth factor (EGF) stimulation and its association with EGF receptor and downstream signaling proteins
• Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells
• Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit, phosphatidylinositol 3-kinase, and p120(CBL)

PIK3CA

• Phosphatidylinositol 3-kinase: structure and expression of the 110 kd catalytic subunit
• PIK3CA as an oncogene in cervical cancer
• High frequency of mutations of the PIK3CA gene in human cancers
• Prospects for phosphoinositide 3-kinase inhibition as a cancer treatment
• Targeting phosphoinositide 3-kinase: moving towards therapy

PIK3CA

Somatic tumors

colorectal, gastric, glioblastoma, breast

Tumor types germline

Cancer Syndrom

Translocation partner

Name

phosphoinositide-3-kinase, catalytic, alpha polypeptide

Chromosome banding

3q26.3

Cancer molecular gen.

Dom

Mutation type

Mis

Other syndrome disease

• Hepatitis B
  Homo sapiens (human) 3 genes

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• Measles
  Homo sapiens (human) 3 genes

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• Influenza A
  Homo sapiens (human) 3 genes

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• HTLV-I infection
  Homo sapiens (human) 3 genes

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• Epstein-Barr virus infection
  Homo sapiens (human) 3 genes

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• Chronic myeloid leukemia
  Homo sapiens (human) 3 genes

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• ErbB signaling pathway
  Homo sapiens (human) 3 genes

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