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multiple myeloma, susceptibility to
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Pathways
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Cancer Gene Census
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CCND1
Somatic tumors
CLL, B-ALL, breast
Tumor types germline
Cancer Syndrom
Translocation partner
IGH, FSTL3
Name
cyclin D1
Chromosome banding
11q13
Cancer molecular gen.
Dom
Mutation type
T
Other syndrome disease
Definition
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Clinical Trials
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External
Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)
PubMed Links
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CCND1
Cyclin D1 in non-small cell lung cancer: a key driver of malignant transformation
Cyclin D1 functions in cell migration
Zinc finger transcription factor INSM1 interrupts cyclin D1 and CDK4 binding and induces cell cycle arrest
Genomic organization, chromosomal localization, and independent expression of human cyclin D genes
Identification and cloning of two overexpressed genes, U21B31/PRAD1 and EMS1, within the amplified chromosome 11q13 region in human carcinomas
Gene rearrangement and overexpression of PRAD1 in lymphoid malignancy with t(11;14)(q13;q32) translocation
PRAD1, a candidate BCL1 oncogene: mapping and expression in centrocytic lymphoma
Human D-type cyclin
Characterization of a candidate bcl-1 gene
Molecular cloning of the chromosomal breakpoint of B-cell lymphomas and leukemias with the t(11;14) chromosome translocation
Evidence for different modes of action of cyclin-dependent kinase inhibitors: p15 and p16 bind to kinases, p21 and p27 bind to cyclins
Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C
Cloning of the gene encoding Trop-2, a cell-surface glycoprotein expressed by human carcinomas
PRAD1/cyclin D1 proto-oncogene: genomic organization, 5' DNA sequence, and sequence of a tumor-specific rearrangement breakpoint