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multiple sclerosis, disease progression
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Cancer Gene Census
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Definition
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Pathways
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PubMed Links
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PDCD1
Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death
Contribution of the PD-L1/PD-1 pathway to T-cell exhaustion: an update on implications for chronic infections and tumor evasion
PD-L1 co-stimulation contributes to ligand-induced T cell receptor down-modulation on CD8+ T cells
Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes
Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation
PD-L2 is a second ligand for PD-1 and inhibits T cell activation
Expression of programmed death 1 ligands by murine T cells and APC
Clinical Trials
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External
Serial [18F]Fluorodeoxyglucose ([18F]FDG )PET/CT as a Biomarker of Therapeutic Response in Anti-PD1/PDL1 Therapy
Study of Optimized Management of Nivolumab Based on Response in Patients With Advanced RCC (OMNIVORE Study)
SBRT +/- Pembrolizumab in Patients With Local-Regionally Recurrent or Second Primary Head and Neck Carcinoma (KEYSTROKE)
Nivolumab in Eliminating Minimal Residual Disease and Preventing Relapse in Patients With Acute Myeloid Leukemia in Remission After Chemotherapy