Medical Knowledge Cockpit mycobacterium tuberculosis

IFNGR1

• Human, mouse, and rat calnexin cDNA cloning: identification of potential calcium binding motifs and gene localization to human chromosome 5
• Ligand-induced IFN gamma receptor tyrosine phosphorylation couples the receptor to its signal transduction system (p91)
• Alignment of disulfide bonds of the extracellular domain of the interferon gamma receptor and investigation of their role in biological activity

IRGM

• Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease

MC3R

• Mapping of the ACTH, MSH, and neural (MC3 and MC4) melanocortin receptors in the mouse and human
• Interaction of dual intracellular signaling pathways activated by the melanocortin-3 receptor

CCL2

• Monocyte chemotactic protein-1 is a potential player in the negative cross-talk between adipose tissue and skeletal muscle
• Induction of brain natriuretic peptide and monocyte chemotactic protein-1 gene expression by oxidized low-density lipoprotein: relevance to ischemic heart failure
• Melatonin improves inflammation processes in liver of senescence-accelerated prone male mice (SAMP8)
• Human monocyte chemoattractant protein-1 (MCP-1)

CD209

• The C type lectins DC-SIGN and L-SIGN: receptors for viral glycoproteins

SP110

• Molecular cloning of two new interferon-induced, highly related nuclear phosphoproteins

TLR2

• Polymorphisms of the toll-like receptor 2 and 4 genes are associated with faster progression and a more severe course of sepsis in critically ill patients
• Lack of association between Toll-like receptor 2 polymorphisms and susceptibility to severe disease caused by Staphylococcus aureus

CD209

Somatic tumors

prostate carcinoma

Tumor types germline

Cancer Syndrom

Translocation partner

Name

CD209 molecule

Chromosome banding

19p13.2

Cancer molecular gen.

Mutation type

Mis

Other syndrome disease

• Hepatitis B
  Homo sapiens (human) one gene

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• PI3K-Akt signaling pathway
  Homo sapiens (human) one gene

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