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myelofibrosis, somatic
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PubMed Links
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MPL
Interferon-alpha directly represses megakaryopoiesis by inhibiting thrombopoietin-induced signaling through induction of SOCS-1.
Thrombopoietin induces phosphoinositol 3-kinase activation through SHP2, Gab, and insulin receptor substrate proteins in BAF3 cells and primary murine megakaryocytes.
Compound heterozygosity for two different amino-acid substitution mutations in the thrombopoietin receptor (c-mpl gene) in congenital amegakaryocytic thrombocytopenia (CAMT).
CALR
HLA-H and associated proteins in patients with hemochromatosis
Calreticulin in cardiac development and pathology
Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2
Somatic mutations of calreticulin in myeloproliferative neoplasms
JAK2
Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK
Tec and Jak2 kinases cooperate to mediate cytokine-driven activation of c-fos transcription
Induction of Jak/STAT signaling by activation of the type 1 TNF receptor
Role of the vav proto-oncogene product (Vav) in erythropoietin-mediated cell proliferation and phosphatidylinositol 3-kinase activity
Findings of scientific misconduct
Prolactin-induced Jak2 phosphorylation of RUSH: a key element in Jak/RUSH signaling
SH2B3
Cloning and characterization of human Lnk, an adaptor protein with pleckstrin homology and Src homology 2 domains that can inhibit T cell activation
Enhanced hematopoiesis by hematopoietic progenitor cells lacking intracellular adaptor protein, Lnk
Lnk negatively regulates self-renewal of hematopoietic stem cells by modifying thrombopoietin-mediated signal transduction
Cancer Gene Census
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MPL
Somatic tumors
MPN
Tumor types germline
MPN
Cancer Syndrom
familial essential thrombocythemia
Translocation partner
Name
myeloproliferative leukaemia virus oncogene, thrombopoietin receptor
Chromosome banding
1p34
Cancer molecular gen.
Dom
Mutation type
Mis
Other syndrome disease
Congenital amegakaryocytic thrombocytopenia
Definition
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Pathways
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bioactive peptide induced signaling pathway
species not specified
one gene
il 3 signaling pathway
species not specified
one gene
no2-dependent il-12 pathway in nk cells
species not specified
one gene
Clinical Trials
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External
JAK Inhibitor Before Donor Stem Cell Transplant in Treating Patients With Primary or Secondary Myelofibrosis