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myelofibrosis with myeloid metaplasia, somatic
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Pathways
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Cancer Gene Census
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MPL
Somatic tumors
MPN
Tumor types germline
MPN
Cancer Syndrom
familial essential thrombocythemia
Translocation partner
Name
myeloproliferative leukaemia virus oncogene, thrombopoietin receptor
Chromosome banding
1p34
Cancer molecular gen.
Dom
Mutation type
Mis
Other syndrome disease
Congenital amegakaryocytic thrombocytopenia
Definition
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PubMed Links
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MPL
A structure-function analysis of serine/threonine phosphorylation of the thrombopoietin receptor, c-Mpl.
Mutations in the thrombopoietin receptor, Mpl, in children with congenital amegakaryocytic thrombocytopenia.
Interferon-alpha directly represses megakaryopoiesis by inhibiting thrombopoietin-induced signaling through induction of SOCS-1.
Clinical Trials
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