Medical Knowledge Cockpit myeloproliferative disorder

FGFR1OP

• The t(6;8)(q27;p11) translocation in a stem cell myeloproliferative disorder fuses a novel gene, FOP, to fibroblast growth factor receptor 1

PDGFRB

• RasGAP Promotes Autophagy and Thereby Suppresses Platelet-Derived Growth Factor Receptor-Mediated Signaling Events, Cellular Responses, and Pathology
• Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice
• Pericyte loss and microaneurysm formation in PDGF-B-deficient mice
• Paracrine PDGF-B/PDGF-Rbeta signaling controls mesangial cell development in kidney glomeruli
• Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities

FGFR1OP

Somatic tumors

MPN, NHL

Tumor types germline

Cancer Syndrom

Translocation partner

FGFR1

Name

FGFR1 oncogene partner (FOP)

Chromosome banding

6q27

Cancer molecular gen.

Dom

Mutation type

T

Other syndrome disease

• Calcium signaling pathway
  Homo sapiens (human) one gene

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