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obesity, severe
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basic mechanism of action of ppara pparb(d) and pparg and effects on gene expression
species not specified
one gene
Clinical Trials
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PPARG
Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism
A PPARgamma mutant serves as a dominant negative inhibitor of PPAR signaling and is localized in the nucleus
Asymmetry in the PPARgamma/RXRalpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors
SIM1
SIM1 overexpression partially rescues agouti yellow and diet-induced obesity by normalizing food intake
Sim1 haploinsufficiency impairs melanocortin-mediated anorexia and activation of paraventricular nucleus neurons
Oxytocin deficiency mediates hyperphagic obesity of Sim1 haploinsufficient mice
UCP3
Uncoupling protein 3 gene is associated with body composition changes with training in HERITAGE study
Muscle UCP-3 mRNA levels are elevated in weight loss associated with gastrointestinal adenocarcinoma in humans
Analysis of microsatellite markers at the UCP2/UCP3 locus on chromosome 11q13 in anorexia nervosa
MC3R
Molecular characterization of human melanocortin-3 receptor ligand-receptor interaction
Molecular cloning of a novel melanocortin receptor
Definition
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Cancer Gene Census
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PPARG
Somatic tumors
follicular thyroid
Tumor types germline
Cancer Syndrom
Translocation partner
PAX8
Name
peroxisome proliferative activated receptor, gamma
Chromosome banding
3p25
Cancer molecular gen.
Dom
Mutation type
T
Other syndrome disease
Insulin resistance ; lipodystrophy, familial partial L;diabetes mellitus, insulin-resistantI, with acanthosis nigricans and hypertension