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HTR2A

This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this geneare associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associatedwith response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients whoalso have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as thisantidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoformshave been found for this gene. (provided by RefSeq, Sep 2009)

This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles

Mutations in this geneare associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associatedwith response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients whoalso have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as thisantidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoformshave been found for this gene. (provided by RefSeq, Sep 2009)

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