Medical Knowledge Cockpit otopalatodigital syndrome, type ii

FLNA

• The small GTPase RalA targets filamin to induce filopodia
• Identification of actin binding protein, ABP-280, as a binding partner of human Lnk adaptor protein
• The Rac1- and RhoG-specific GEF domain of Trio targets filamin to remodel cytoskeletal actin

FLNA

Somatic tumors

phyllodes tumour of the breast

Tumor types germline

Cancer Syndrom

Translocation partner

Name

filamin A

Chromosome banding

Xq28

Cancer molecular gen.

Mutation type

Mis, F, O

Other syndrome disease