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paroxysmal nocturnal hemoglobinuria
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Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
Homo sapiens (human)
2 genes
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PIGT
PIG-S and PIG-T, essential for GPI anchor attachment to proteins, form a complex with GAA1 and GPI8
PIGA
Deficiency of the GPI anchor caused by a somatic mutation of the PIG-A gene in paroxysmal nocturnal hemoglobinuria
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