Medical Knowledge Cockpit platelet disorder, familial, with associated myeloid malignancy

RUNX1

• SLC22A4 and RUNX1: identification of RA susceptible genes
• Implications of somatic mutations in the AML1/RUNX1 gene in myelodysplastic syndrome (MDS): future molecular therapeutic directions for MDS
• Linkage mapping of the AML1 gene on human chromosome 21 using a DNA polymorphism in the 3' untranslated region
• RUNX1/AML1: a central player in hematopoiesis

RUNX1

Somatic tumors

AML, pre B-ALL, T-ALL

Tumor types germline

Cancer Syndrom

Translocation partner

RPL22, MECOM, CBFA2T3, RUNX1T1, ETV6, AFF3

Name

runt-related transcription factor 1 (AML1)

Chromosome banding

21q22.3

Cancer molecular gen.

Dom

Mutation type

T

Other syndrome disease