Medical Knowledge Cockpit pleuropulmonary blastoma

DICER1

• Role for a bidentate ribonuclease in the initiation step of RNA interference
• Role of Dicer in posttranscriptional RNA silencing
• Transcriptional control of gene expression by microRNAs

DICER1

Somatic tumors

sex cord-stromal tumour, TGCT, embryonal rhabdomyosarcoma, pleuropulmonary blastoma, pituitary blastoma, Wilms tumour, thyroid cancer, other tumour types

Tumor types germline

pleuropulmonary blastoma

Cancer Syndrom

familial pleuropulmonary blastoma or DICER1 syndrome

Translocation partner

Name

dicer 1, ribonuclease type III

Chromosome banding

14q32.13

Cancer molecular gen.

Rec

Mutation type

Mis, F, N

Other syndrome disease