Medical Knowledge Cockpit polycythemia vera

JAK2

• SH2-Containing protein tyrosine phosphatase-1 (SHP-1) association with Jak2 in UT-7/Epo cells
• The human homologue of the yeast proteins Skb1 and Hsl7p interacts with Jak kinases and contains protein methyltransferase activity
• Identification of SH2-Bbeta as a substrate of the tyrosine kinase JAK2 involved in growth hormone signaling
• Jak2 is involved in c-Myc induction by Bcr-Abl
• Growth hormone-promoted tyrosyl phosphorylation of SHC proteins and SHC association with Grb2

• Shc mediates IL-6 signaling by interacting with gp130 and Jak2 kinase

JAK2

Somatic tumors

ALL, AML, MPN, CML

Tumor types germline

Cancer Syndrom

Translocation partner

ETV6, PCM1, BCR

Name

Janus kinase 2

Chromosome banding

9p24

Cancer molecular gen.

Dom

Mutation type

T, Mis, O

Other syndrome disease