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polyposis
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Cleavage of the damaged purine
species not specified
one gene
Hippo signaling pathway
Homo sapiens (human)
3 genes
Clinical Trials
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Clinical Sequencing of Cancer and Tissue Repository: OncoGenomics
Definition
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Cancer Gene Census
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MUTYH
Somatic tumors
Tumor types germline
colorectal
Cancer Syndrom
adenomatous polyposis coli
Translocation partner
Name
mutY homolog (E. coli)
Chromosome banding
1p34.3-1p32.1
Cancer molecular gen.
Rec
Mutation type
Mis
Other syndrome disease
PubMed Links
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APC
Critical role for the EB1 and APC interaction in the regulation of microtubule polymerization
The tyrosine kinase substrate p120cas binds directly to E-cadherin but not to the adenomatous polyposis coli protein or alpha-catenin
Association of plakoglobin with APC, a tumor suppressor gene product, and its regulation by tyrosine phosphorylation
MUTYH
Increased frequency of the k-ras G12C mutation in MYH polyposis colorectal adenomas
Role of inherited defects of MYH in the development of sporadic colorectal cancer
MSH2
Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells
Nuclear translocation of mismatch repair proteins MSH2 and MSH6 as a response of cells to alkylating agents
Structural, molecular and cellular functions of MSH2 and MSH6 during DNA mismatch repair, damage signaling and other noncanonical activities
MLH1
The Bloom's syndrome protein (BLM) interacts with MLH1 but is not required for DNA mismatch repair
Cleavage of the Bloom's syndrome gene product during apoptosis by caspase-3 results in an impaired interaction with topoisomerase IIIalpha
Direct association of Bloom's syndrome gene product with the human mismatch repair protein MLH1
PMS2
Childhood brain tumours due to germline bi-allelic mismatch repair gene mutations
Evidence for a recessive inheritance of Turcot's syndrome caused by compound heterozygous mutations within the PMS2 gene
MSH6
Familial endometrial cancer in female carriers of MSH6 germline mutations
Association of hereditary nonpolyposis colorectal cancer-related tumors displaying low microsatellite instability with MSH6 germline mutations
Germ-line msh6 mutations in colorectal cancer families
BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures
TGFBR2
Crystal structure of the human TbetaR2 ectodomain--TGF-beta3 complex
MLH3
MLH3: a DNA mismatch repair gene associated with mammalian microsatellite instability
EPCAM
Edrecolomab alone or in combination with fluorouracil and folinic acid in the adjuvant treatment of stage III colon cancer: a randomised study
BMPR1A
Physical and functional interaction of murine and Xenopus Smad7 with bone morphogenetic protein receptors and transforming growth factor-beta receptors
Bone morphogenetic proteins and growth and differentiation factors in the human cornea
Chromosomal localization of three human genes encoding bone morphogenetic protein receptors