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RET

Somatic tumors
medullary thyroid, papillary thyroid, pheochromocytoma, NSCLC, Spitzoid tumour
Tumor types germline
medullary thyroid, papillary thyroid, pheochromocytoma
Cancer Syndrom
multiple endocrine neoplasia 2A/2B
Translocation partner
H4, PRKAR1A, NCOA4, PCM1, GOLGA5, TRIM33, KTN1, TRIM27, HOOK3, KIF5B, CCDC6
Name
ret proto-oncogene
Chromosome banding
10q11.2
Cancer molecular gen.
Dom
Mutation type
T, Mis, N, F
Other syndrome disease
Hirschsprung disease
Definition     No results

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RET

This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which arecell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial rolein neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogeneticrearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA,multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcriptvariants encoding different isoforms have been found for this gene. Additional transcript variants have beendescribed but their biological validity has not been confirmed. (provided by RefSeq, Jul 2008)

This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which arecell-surface molecules that transduce signals for cell growth and differentiation

This gene plays a crucial rolein neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogeneticrearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA,multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcriptvariants encoding different isoforms have been found for this gene. Additional transcript variants have beendescribed but their biological validity has not been confirmed. (provided by RefSeq, Jul 2008)

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