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renal cell carcinoma, papillary, familial and somatic
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Cancer Gene Census
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MET
Somatic tumors
papillary renal, head-neck squamous cell
Tumor types germline
papillary renal
Cancer Syndrom
familial papillary renal cancer
Translocation partner
Name
met proto-oncogene (hepatocyte growth factor receptor)
Chromosome banding
7q31
Cancer molecular gen.
Dom
Mutation type
Mis
Other syndrome disease
PubMed Links
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MET
Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product
Localization of the 5' end of the MCF2 oncogene to human chromosome 15q15----q23
The met oncogene: from detection by transfection to transmembrane receptor for hepatocyte growth factor
Selective tumorigenesis in non-parenchymal liver epithelial cell lines by hepatocyte growth factor transfection
Evidence for autocrine basis of transformation in NIH-3T3 cells transfected with met/HGF receptor gene
The human met oncogene is related to the tyrosine kinase oncogenes
Met, metastasis, motility and more
Phosphorylation of serine 985 negatively regulates the hepatocyte growth factor receptor kinase
Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein
A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family
Uncoupling of Grb2 from the Met receptor in vivo reveals complex roles in muscle development
Hepatocyte growth factor-induced signal transduction in two normal mouse epithelial cell lines
Clinical Trials
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External
Genetic Analysis of Birt Hogg-Dube Syndrome and Characterization of Predisposition to Kidney Cancer