Medical Knowledge Cockpit renal cell carcinoma, papillary

• Melanoma
  Homo sapiens (human) one gene

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TFE3

Somatic tumors

papillary renal, alveolar soft part sarcoma, renal

Tumor types germline

Cancer Syndrom

Translocation partner

SFPQ, ASPSCR1, PRCC, NONO, CLTC

Name

transcription factor binding to IGHM enhancer 3

Chromosome banding

Xp11.22

Cancer molecular gen.

Dom

Mutation type

T

Other syndrome disease

TFE3

• Fusion of the transcription factor TFE3 gene to a novel gene, PRCC, in t(X;1)(p11;q21)-positive papillary renal cell carcinomas
• Fusion of splicing factor genes PSF and NonO (p54nrb) to the TFE3 gene in papillary renal cell carcinoma
• Synergistic cooperation of TFE3 and smad proteins in TGF-beta-induced transcription of the plasminogen activator inhibitor-1 gene

MET

• Hepatocyte growth factor induces Wnt-independent nuclear translocation of beta-catenin after Met-beta-catenin dissociation in hepatocytes
• Activation of Notch-mediated protective signaling in the myocardium
• Hepatocyte growth factor induces proliferation and morphogenesis in nonparenchymal epithelial liver cells
• Invasive growth: a MET-driven genetic programme for cancer and stem cells
• Developmental roles of HGF/SF and its receptor, the c-Met tyrosine kinase

• Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor
• Beta 1-integrin-c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes
• Hepatocyte growth factor and its receptor are expressed in cardiac myocytes during early cardiogenesis
• Hepatocyte growth factor expression in the developing myocardium: evidence for a role in the regulation of the mesenchymal cell phenotype and urokinase expression
• Met signaling in cardiomyocytes is required for normal cardiac function in adult mice
• Activated Met signalling in the developing mouse heart leads to cardiac disease
• Ets transcription factors cooperate with Sp1 to activate the human tenascin-C promoter

PRCC

• The t(X;1)(p11.2;q21.2) translocation in papillary renal cell carcinoma fuses a novel gene PRCC to the TFE3 transcription factor gene