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renal dysplasia
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GATA3
Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor delta gene enhancer
Activation of the interleukin-5 promoter by cAMP in murine EL-4 cells requires the GATA-3 and CLE0 elements
Structure and expression of the human GATA3 gene
Transcriptional activity of TAL1 in T cell acute lymphoblastic leukemia (T-ALL) requires RBTN1 or -2 and induces TALLA1, a highly specific tumor marker of T-ALL
TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3
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Cancer Gene Census
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GATA3
Somatic tumors
breast
Tumor types germline
Cancer Syndrom
Translocation partner
Name
GATA binding protein 3
Chromosome banding
10p15
Cancer molecular gen.
Rec
Mutation type
F, N, S
Other syndrome disease
HDR syndrome (hypoparathyroidism, sensorineural deafness, and renal disease)
Pathways
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gata3 participate in activating the th2 cytokine genes expression
species not specified
one gene
Clinical Trials
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