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HRAS

Somatic tumors
infrequent sarcomas, rare other tumour types
Tumor types germline
rhabdomyosarcoma, ganglioneuroblastoma, bladder
Cancer Syndrom
Costello syndrome
Translocation partner
Name
v-Ha-ras Harvey rat sarcoma viral oncogene homolog
Chromosome banding
11p15.5
Cancer molecular gen.
Dom
Mutation type
Mis
Other syndrome disease
Definition     No results

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HRAS

This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammaliansarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. Theseproteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycleof de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgiapparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at theprenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation,skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defectsin this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, andoral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identifiedfor this gene. (provided by RefSeq, Jul 2008)

This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammaliansarcoma retroviruses

The products encoded by these genes function in signal transduction pathways. Theseproteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycleof de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgiapparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at theprenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation,skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defectsin this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, andoral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identifiedfor this gene. (provided by RefSeq, Jul 2008)

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