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Pathways
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t cell receptor signaling pathway
species not specified
2 genes
activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor
species not specified
2 genes
Cancer Gene Census
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JAK3
Somatic tumors
acute megakaryocytic leukaemia, ETP ALL
Tumor types germline
Cancer Syndrom
Translocation partner
Name
Janus kinase 3
Chromosome banding
19p13.1
Cancer molecular gen.
Dom
Mutation type
Mis
Other syndrome disease
Clinical Trials
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External
Phase IV, GSK2696273, Registry Study to Follow-up Patients With Adenosine Deaminase Severe Combined Immunodeficiency (ADA-SCID)
Definition
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PubMed Links
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CD3E
Specific interaction of topoisomerase II beta and the CD3 epsilon chain of the T cell receptor complex
CAST, a novel CD3epsilon-binding protein transducing activation signal for interleukin-2 production in T cells
Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation
Therapeutic biology: checkpoint pathway activation therapy, HIV Tat, and transkingdom RNA interference
LCK
The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex
Regulation of Fyn through translocation of activated Lck into lipid rafts
Lck-dependent Fyn activation requires C terminus-dependent targeting of kinase-active Lck to lipid rafts
Negative regulation of Lck by Cbl ubiquitin ligase
Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases
The SH3 domain of p56lck binds to proline-rich sequences in the cytoplasmic domain of CD2
JAK3
Targeting IL-15 receptor-bearing cells with an antagonist mutant IL-15/Fc protein prevents disease development and progression in murine collagen-induced arthritis
IL-9-deficient mice establish fundamental roles for IL-9 in pulmonary mastocytosis and goblet cell hyperplasia but not T cell development
CP-690550, a JAK3 inhibitor as an immunosuppressant for the treatment of rheumatoid arthritis, transplant rejection, psoriasis and other immune-mediated disorders
Cytokine-independent Jak3 activation upon T cell receptor (TCR) stimulation through direct association of Jak3 and the TCR complex
A novel protein MAJN binds to Jak3 and inhibits apoptosis induced by IL-2 deprival