Medical Knowledge Cockpit severe combined immunodeficiency, t cell-negative

PTPRC

Somatic tumors

T-ALL

Tumor types germline

Cancer Syndrom

Translocation partner

Name

protein tyrosine phosphatase, receptor type, C

Chromosome banding

1q31-q32

Cancer molecular gen.

Rec

Mutation type

Mis, N, S

Other syndrome disease

PTPRC

• Interleukin-6, CD45 and the src-kinases in myeloma cell proliferation.
• CD45 variant alleles: possibly increased frequency of a novel exon 4 CD45 polymorphism in HIV seropositive Ugandans.