Medical Knowledge Cockpit shprintzen-goldberg syndrome

SKI

• SKI pathways inducing progression of human melanoma
• Crystal structure of the dachshund homology domain of human SKI
• Competition between Ski and CREB-binding protein for binding to Smad proteins in transforming growth factor-beta signaling
• Drosophila SnoN modulates growth and patterning by antagonizing TGF-beta signalling
• Fussel-15, a novel Ski/Sno homolog protein, antagonizes BMP signaling

SKI

Somatic tumors

melanoma

Tumor types germline

Cancer Syndrom

Translocation partner

Name

SKI proto-oncogene

Chromosome banding

1p36.33-p36.32

Cancer molecular gen.

Mutation type

Mis

Other syndrome disease