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RB1
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RB1
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RB1
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor genefound. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatinstructure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in thisgene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. (provided byRefSeq, Jul 2008)The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor genefound
The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatinstructure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in thisgene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. (provided byRefSeq, Jul 2008)
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