Medical Knowledge Cockpit squamous cell carcinoma

 

• pten dependent cell cycle arrest and apoptosis
  species not specified one gene

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• mtor signaling pathway
  species not specified one gene

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• regulation of eif-4e and p70s6 kinase
  species not specified one gene

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TNFRSF10B

The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular deathdomain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand(TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD,a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcriptvariants encoding different isoforms and one non-coding transcript have been found for this gene. (provided byRefSeq, Mar 2009)

The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular deathdomain

This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand(TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD,a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcriptvariants encoding different isoforms and one non-coding transcript have been found for this gene. (provided byRefSeq, Mar 2009)

 

PTEN

Somatic tumors

glioma, prostate, endometrial

Tumor types germline

harmartoma, glioma, prostate, endometrial

Cancer Syndrom

Cowden syndrome, Bannayan-Riley-Ruvalcaba syndrome

Translocation partner

Name

phosphatase and tensin homolog gene

Chromosome banding

10q23.3

Cancer molecular gen.

Dom

Mutation type

D, Mis, N, F, S

Other syndrome disease

DEC1

• Isolation and mutational analysis of a novel human cDNA, DEC1 (deleted in esophageal cancer 1), derived from the tumor suppressor locus in 9q32

LZTS1

• Fez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes mice to cancer development

WWOX

• Functional association between Wwox tumor suppressor protein and p73, a p53 homolog
• The tumor suppressor gene WWOX at FRA16D is involved in pancreatic carcinogenesis
• The fragile genes FHIT and WWOX are inactivated coordinately in invasive breast carcinoma

RSPO1

• R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6

TNFRSF10B

• An antagonist decoy receptor and a death domain-containing receptor for TRAIL
• Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors
• TRICK2, a new alternatively spliced receptor that transduces the cytotoxic signal from TRAIL

ING1

• The candidate tumor suppressor ING1b can stabilize p53 by disrupting the regulation of p53 by MDM2
• The candidate tumour suppressor p33ING1 cooperates with p53 in cell growth control
• UV-induced binding of ING1 to PCNA regulates the induction of apoptosis

PTEN

• PTEN function: how normal cells control it and tumour cells lose it
• The biology and clinical relevance of the PTEN tumor suppressor pathway
• Protean PTEN: form and function
• Germline PTEN promoter mutations and deletions in Cowden/Bannayan-Riley-Ruvalcaba syndrome result in aberrant PTEN protein and dysregulation of the phosphoinositol-3-kinase/Akt pathway
• Disruption of PTEN coupling with 5-HT2C receptors suppresses behavioral responses induced by drugs of abuse