Medical Knowledge Cockpit stroke, susceptibility to

• intrinsic prothrombin activation pathway
  species not specified 2 genes

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• Complement and coagulation cascades
  Homo sapiens (human) 2 genes

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• corticosteroids and cardioprotection
  species not specified 2 genes

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NOS3

• Endothelial nitric oxide synthase genotypes and haplotypes modify the responses to sildenafil in patients with erectile dysfunction
• Pharmacogenetics of erectile dysfunction: navigating into uncharted waters
• Pharmacogenetics of erectile dysfunction: navigating into uncharted waters
• Aberrant expression of nitric oxide synthase III in Alzheimer's disease: relevance to cerebral vasculopathy and neurodegeneration
• Aberrant expression of nitric oxide synthase III in Alzheimer's disease: relevance to cerebral vasculopathy and neurodegeneration

• Regulation of endothelial nitric oxide synthase: location, location, location
• Regulation of endothelial nitric oxide synthase: location, location, location
• Regulation of endothelial nitric oxide synthase activity and gene expression
• Regulation of endothelial nitric oxide synthase activity and gene expression
• Regulation of endothelial nitric oxide synthase by tetrahydrobiopterin in vascular disease
• Regulation of endothelial nitric oxide synthase by tetrahydrobiopterin in vascular disease
• Endothelial nitric oxide synthase: a new paradigm for gene regulation in the injured blood vessel
• Endothelial nitric oxide synthase: a new paradigm for gene regulation in the injured blood vessel
• Dysfunction of endothelial nitric oxide synthase and atherosclerosis
• Dysfunction of endothelial nitric oxide synthase and atherosclerosis
• Role of eNOS in neovascularization: NO for endothelial progenitor cells
• Role of eNOS in neovascularization: NO for endothelial progenitor cells
• Molecular cloning and characterization of human endothelial nitric oxide synthase

F2

• Thrombin and phenotypic modulation of the endothelium
• Thrombin domains: structure, function and interaction with platelet receptors
• Role of thrombin in angiogenesis and tumor progression
• Structure and interaction modes of thrombin

F5

• Factor V deficiency: a concise review
• The discovery of factor V: a tricky clotting factor

PDE4D

• mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module
• Identification of a surface on the beta-propeller protein RACK1 that interacts with the cAMP-specific phosphodiesterase PDE4D5
• Localization of a susceptibility gene for common forms of stroke to 5q12
• Inhibition of PDE3B augments PDE4 inhibitor-induced apoptosis in a subset of patients with chronic lymphocytic leukemia

ALOX5AP

• Lipid mediators in the resolution of inflammation
• Crystal structure of inhibitor-bound human 5-lipoxygenase-activating protein
• 5-Lipoxygenase (ALOX5) and FLAP (ALOX5AP) gene polymorphisms as factors in vascular pathology and Alzheimer's disease