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Cancer Gene Census     No results

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PTEN

Somatic tumors
glioma, prostate, endometrial
Tumor types germline
harmartoma, glioma, prostate, endometrial
Cancer Syndrom
Cowden syndrome, Bannayan-Riley-Ruvalcaba syndrome
Translocation partner
Name
phosphatase and tensin homolog gene
Chromosome banding
10q23.3
Cancer molecular gen.
Dom
Mutation type
D, Mis, N, F, S
Other syndrome disease
Definition     No results

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PTEN

This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. Theprotein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin likedomain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases.Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositidesubstrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells andfunctions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. (provided by RefSeq, Jul2008)

This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency

Theprotein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin likedomain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases.Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositidesubstrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells andfunctions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. (provided by RefSeq, Jul2008)

Pathways     No results

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  • il 3 signaling pathway
    species not specified one gene
  • insulin signaling pathway
    species not specified one gene
  • trka receptor signaling pathway
    species not specified one gene
  • phosphorylation of mek1 by cdk5/p35 down regulates the map kinase pathway
    species not specified one gene
  • mets affect on macrophage differentiation
    species not specified one gene
  • skeletal muscle hypertrophy is regulated via akt-mtor pathway
    species not specified one gene
  • fmlp induced chemokine gene expression in hmc-1 cells
    species not specified one gene
  • mapkinase signaling pathway
    species not specified one gene
  • bioactive peptide induced signaling pathway
    species not specified one gene
  • role of erk5 in neuronal survival pathway
    species not specified one gene
  • epo signaling pathway
    species not specified one gene
  • links between pyk2 and map kinases
    species not specified one gene
  • nerve growth factor pathway (ngf)
    species not specified one gene
Clinical Trials     No results

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