An error occurred
PTEN
An error occurred
PTEN
An error occurred
PTEN
This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. Theprotein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin likedomain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases.Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositidesubstrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells andfunctions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. (provided by RefSeq, Jul2008)This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency
Theprotein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin likedomain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases.Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositidesubstrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells andfunctions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. (provided by RefSeq, Jul2008)
An error occurred
An error occurred