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Cancer Gene Census     No results

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PTEN

Somatic tumors
glioma, prostate, endometrial
Tumor types germline
harmartoma, glioma, prostate, endometrial
Cancer Syndrom
Cowden syndrome, Bannayan-Riley-Ruvalcaba syndrome
Translocation partner
Name
phosphatase and tensin homolog gene
Chromosome banding
10q23.3
Cancer molecular gen.
Dom
Mutation type
D, Mis, N, F, S
Other syndrome disease
Definition     No results

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PTEN

This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. Theprotein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin likedomain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases.Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositidesubstrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells andfunctions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. (provided by RefSeq, Jul2008)

This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency

Theprotein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin likedomain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases.Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositidesubstrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells andfunctions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. (provided by RefSeq, Jul2008)

Pathways     No results

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  • mcalpain and friends in cell motility
    species not specified one gene
  • il 6 signaling pathway
    species not specified one gene
  • signaling pathway from g-protein families
    species not specified one gene
  • map kinase inactivation of smrt corepressor
    species not specified one gene
  • role of mal in rho-mediated activation of srf
    species not specified one gene
  • how progesterone initiates the oocyte maturation
    species not specified one gene
  • sprouty regulation of tyrosine kinase signals
    species not specified one gene
  • roles of beta arrestin dependent recruitment of src kinases in gpcr signaling
    species not specified {:one=>"one gene", :other=>"%{count} genes"}
  • nfat and hypertrophy of the heart
    species not specified {:one=>"one gene", :other=>"%{count} genes"}
  • Melanoma
    Homo sapiens (human) 3 genes
  • PI3K-Akt signaling pathway
    Homo sapiens (human) 3 genes
  • Prostate cancer
    Homo sapiens (human) 3 genes
  • Glioma
    Homo sapiens (human) 3 genes
Clinical Trials     No results

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