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Cancer Gene Census     No results

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PTEN

Somatic tumors
glioma, prostate, endometrial
Tumor types germline
harmartoma, glioma, prostate, endometrial
Cancer Syndrom
Cowden syndrome, Bannayan-Riley-Ruvalcaba syndrome
Translocation partner
Name
phosphatase and tensin homolog gene
Chromosome banding
10q23.3
Cancer molecular gen.
Dom
Mutation type
D, Mis, N, F, S
Other syndrome disease
Definition     No results

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HRAS

This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammaliansarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. Theseproteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycleof de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgiapparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at theprenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation,skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defectsin this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, andoral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identifiedfor this gene. (provided by RefSeq, Jul 2008)

This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammaliansarcoma retroviruses

The products encoded by these genes function in signal transduction pathways. Theseproteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycleof de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgiapparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at theprenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation,skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defectsin this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, andoral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identifiedfor this gene. (provided by RefSeq, Jul 2008)

Pathways     No results

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  • ccr3 signaling in eosinophils
    species not specified one gene
  • vegf hypoxia and angiogenesis
    species not specified one gene
  • inhibition of cellular proliferation by gleevec
    species not specified one gene
  • il 6 signaling pathway
    species not specified one gene
  • map kinase inactivation of smrt corepressor
    species not specified one gene
  • role of mal in rho-mediated activation of srf
    species not specified one gene
  • sprouty regulation of tyrosine kinase signals
    species not specified one gene
  • fmlp induced chemokine gene expression in hmc-1 cells
    species not specified one gene
  • skeletal muscle hypertrophy is regulated via akt-mtor pathway
    species not specified one gene
  • mets affect on macrophage differentiation
    species not specified one gene
  • nfat and hypertrophy of the heart
    species not specified {:one=>"one gene", :other=>"%{count} genes"}
  • roles of beta arrestin dependent recruitment of src kinases in gpcr signaling
    species not specified {:one=>"one gene", :other=>"%{count} genes"}
  • Pathways in cancer
    Homo sapiens (human) 6 genes
  • Thyroid cancer
    Homo sapiens (human) 5 genes
Clinical Trials     No results

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