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xeroderma pigmentosum, group e, ddb-negative subtype
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Definition
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DDB2
Somatic tumors
Tumor types germline
skin basal cell, skin squamous cell, melanoma
Cancer Syndrom
xeroderma pigmentosum (E)
Translocation partner
Name
damage-specific DNA binding protein 2
Chromosome banding
11p12
Cancer molecular gen.
Rec
Mutation type
Mis, N
Other syndrome disease
PubMed Links
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DDB2
DDB1-DDB2 (xeroderma pigmentosum group E) protein complex recognizes a cyclobutane pyrimidine dimer, mismatches, apurinic/apyrimidinic sites, and compound lesions in DNA
Dynamic in vivo interaction of DDB2 E3 ubiquitin ligase with UV-damaged DNA is independent of damage-recognition protein XPC
PARP1 promotes nucleotide excision repair through DDB2 stabilization and recruitment of ALC1
Damaged DNA-binding protein down-regulates epigenetic mark H3K56Ac through histone deacetylase 1 and 2
Clinical Trials
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